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Published in February issue of Elsevier's Maturitas
Amsterdam, February 28, 2012 - Elsevier, a world-leading provider of scientific, technical and medical information products and services, announced today the publication of an important clinical guide from the European Menopause and Andropause Society (EMAS) in the February issue of Maturitas. This clinical guide details the role of selective estrogen receptor modulators (SERMs) against postmenopausal osteoporosis as the European Medicines Agency (EMA) has approved the use of bazedoxifene and lasofoxifene.
Postmenopausal osteoporosis and resulting fractures have a major impact on morbidity and mortality and are major public health issues. Various therapies such as bisphosphonates, strontium ranelate and more recently denomsumab are available but these are not suitable for all women. Health concerns have been raised resulting from these therapies, such as oesophageal cancer, osteonecrosis of the jaw (ONJ) and subtrochanteric fractures with bisphosphonates and venous thromboembolism with strontiumranelate. Use of bazedoxifene and lasofoxifene will increase the number of therapeutic options available as these new SERMs point to a greater anti-fracture potential.
The decision of which type of treatment to use for osteoporosis and when to begin should be based on the need to reduce fracture risk. All treatments including SERMs should include recommendations for a healthy life style and adequate calcium and vitamin D intake. Additional benefits of different agents (i.e. climacteric symptom improvement with estrogens, breast cancer prevention for SERMS) must be considered when selecting the anti-osteoporosis drug. Furthermore what agent is used (estrogen, SERM, bisphosphonates) may vary over a woman's life time. The clinical guide from the European Menopause and Andropause Society (EMAS) details all important and necessary aspects of consideration.
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The guide is "Selective estrogen receptor modulators for postmenopausal osteoporosis" Santiago Palacios, Mark Brincat, C. Tamer Erel, Marco Gambacciani, Irene Lambrinoudaki, Mette H. Moen, Karin Schenck-Gustafsson, Florence Tremollieres, Svetlana Vujovic,
Margaret Rees, Serge Rozenberg (doi:10.1016/j.maturitas.2011.11.010). The article appears in Maturitas Volume 71, Issue 2 (February 2012) published by Elsevier.
About European Menopause and Andropause Society (EMAS)
The European Menopause and Andropause Society (EMAS) is an international society that promotes the study and dissemination of research into all aspects of midlife health and beyond in both men and women. Through its activities, EMAS aims to guarantee and provide the same standard of education and information throughout Europe on postreproductive health in both genders. The statutes of EMAS have been submitted to and accepted by the Swiss Authorities and the Society is now acknowledged by the Swiss Government and the International Menopause Society as the official Regional European Menopause Society. EMAS also belongs to the Council of affiliated Menopause Societies (CAMS) of the International Menopause Society (IMS). For more information go to: http://www.emas-online.org/Pages/home.aspx
About Maturitas
Maturitas is an international multidisciplinary peer reviewed scientific journal of midlife health and beyond, publishing original research, reviews, consensus statements and guidelines. The scope encompasses all aspects of postreproductive health in both genders ranging from basic science to health and social care.
About Elsevier
Elsevier is a world-leading publisher of scientific, technical and medical information products and services. The company works in partnership with the global science and health communities to publish more than 2,000 journals, including The Lancet and Cell, and close to 20,000 book titles, including major reference works from Mosby and Saunders. Elsevier's online solutions include SciVerse ScienceDirect, SciVerse Scopus, Reaxys, MD Consult and Nursing Consult, which enhance the productivity of science and health professionals, and the SciVal suite and MEDai's Pinpoint Review, which help research and health care institutions deliver better outcomes more cost-effectively.
A global business headquartered in Amsterdam, Elsevier employs 7,000 people worldwide. The company is part of Reed Elsevier Group PLC, a world-leading publisher and information provider, which is jointly owned by Reed Elsevier PLC and Reed Elsevier NV. The ticker symbols are REN (Euronext Amsterdam), REL (London Stock Exchange), RUK and ENL (New York Stock Exchange).
Media contact
Greyling Peoples
Elsevier
+31 20 485 3323
g.peoples@elsevier.com
[ | E-mail | Share ]
?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Clinical guide on selective estrogen receptor modulators for postmenopausal osteoporosisPublic release date: 28-Feb-2012 [ | E-mail | Share ]
Published in February issue of Elsevier's Maturitas
Amsterdam, February 28, 2012 - Elsevier, a world-leading provider of scientific, technical and medical information products and services, announced today the publication of an important clinical guide from the European Menopause and Andropause Society (EMAS) in the February issue of Maturitas. This clinical guide details the role of selective estrogen receptor modulators (SERMs) against postmenopausal osteoporosis as the European Medicines Agency (EMA) has approved the use of bazedoxifene and lasofoxifene.
Postmenopausal osteoporosis and resulting fractures have a major impact on morbidity and mortality and are major public health issues. Various therapies such as bisphosphonates, strontium ranelate and more recently denomsumab are available but these are not suitable for all women. Health concerns have been raised resulting from these therapies, such as oesophageal cancer, osteonecrosis of the jaw (ONJ) and subtrochanteric fractures with bisphosphonates and venous thromboembolism with strontiumranelate. Use of bazedoxifene and lasofoxifene will increase the number of therapeutic options available as these new SERMs point to a greater anti-fracture potential.
The decision of which type of treatment to use for osteoporosis and when to begin should be based on the need to reduce fracture risk. All treatments including SERMs should include recommendations for a healthy life style and adequate calcium and vitamin D intake. Additional benefits of different agents (i.e. climacteric symptom improvement with estrogens, breast cancer prevention for SERMS) must be considered when selecting the anti-osteoporosis drug. Furthermore what agent is used (estrogen, SERM, bisphosphonates) may vary over a woman's life time. The clinical guide from the European Menopause and Andropause Society (EMAS) details all important and necessary aspects of consideration.
###
The guide is "Selective estrogen receptor modulators for postmenopausal osteoporosis" Santiago Palacios, Mark Brincat, C. Tamer Erel, Marco Gambacciani, Irene Lambrinoudaki, Mette H. Moen, Karin Schenck-Gustafsson, Florence Tremollieres, Svetlana Vujovic,
Margaret Rees, Serge Rozenberg (doi:10.1016/j.maturitas.2011.11.010). The article appears in Maturitas Volume 71, Issue 2 (February 2012) published by Elsevier.
About European Menopause and Andropause Society (EMAS)
The European Menopause and Andropause Society (EMAS) is an international society that promotes the study and dissemination of research into all aspects of midlife health and beyond in both men and women. Through its activities, EMAS aims to guarantee and provide the same standard of education and information throughout Europe on postreproductive health in both genders. The statutes of EMAS have been submitted to and accepted by the Swiss Authorities and the Society is now acknowledged by the Swiss Government and the International Menopause Society as the official Regional European Menopause Society. EMAS also belongs to the Council of affiliated Menopause Societies (CAMS) of the International Menopause Society (IMS). For more information go to: http://www.emas-online.org/Pages/home.aspx
About Maturitas
Maturitas is an international multidisciplinary peer reviewed scientific journal of midlife health and beyond, publishing original research, reviews, consensus statements and guidelines. The scope encompasses all aspects of postreproductive health in both genders ranging from basic science to health and social care.
About Elsevier
Elsevier is a world-leading publisher of scientific, technical and medical information products and services. The company works in partnership with the global science and health communities to publish more than 2,000 journals, including The Lancet and Cell, and close to 20,000 book titles, including major reference works from Mosby and Saunders. Elsevier's online solutions include SciVerse ScienceDirect, SciVerse Scopus, Reaxys, MD Consult and Nursing Consult, which enhance the productivity of science and health professionals, and the SciVal suite and MEDai's Pinpoint Review, which help research and health care institutions deliver better outcomes more cost-effectively.
A global business headquartered in Amsterdam, Elsevier employs 7,000 people worldwide. The company is part of Reed Elsevier Group PLC, a world-leading publisher and information provider, which is jointly owned by Reed Elsevier PLC and Reed Elsevier NV. The ticker symbols are REN (Euronext Amsterdam), REL (London Stock Exchange), RUK and ENL (New York Stock Exchange).
Media contact
Greyling Peoples
Elsevier
+31 20 485 3323
g.peoples@elsevier.com
[ | E-mail | Share ]
?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
[unable to retrieve full-text content]February 24, 2012 | Author: John A. Ballard | Posted in Health & Fitness. You can actually avoid going to the doctor and treat hemorrhoids in your home, you can use methods like witch hazel, analgesics, sitz baths, topical cream or NSAIDS.
[unable to retrieve full-text content]AP - Soaring gasoline prices are threatening to undercut President Barack Obama's re-election prospects and offering Republicans an easy target. With prices pushing $4 a gallon and threatening to go even higher, Obama sought Thursday to confront rising public anxiety and strike back at his GOP critics.
It is said that the song Wipe Out launched a generation of drummers.? In the world of information security, the classic Applied Cryptography: Protocols, Algorithms, and Source Code in C by Bruce Schenier may have been the book that launched a generation of new cryptographers.
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Schenier latest work of art is Liars and Outliers: Enabling the Trust that Society Needs to Thrive.? For those that are looking for a follow-up to Applied Cryptography, this it is not.? In fact, it is hard to classify this as an information security title and in fact the book is marked for the current affairs / sociology section.? Whatever section this book ultimately falls in, the reader will find that Schneier is one of the most original thinkers around.
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In Applied Cryptography Schneier dealt with the pristine world of mathematical cryptography where aspects of pure mathematics could be demonstrably proven.? For example, non-repudiation is absolutely provable.?
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In Liars and Outliers, Schneier moves from the pristine world of mathematics into the muddy world of human trust.? Non-repudiation is no longer an absolute in a world where a Windows kernel can be compromised and end-users can be victims of social engineering.
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The book addresses the fundamental question of how does society function when you can't trust everyone.? Schneier notes that nothing in society works without trust.? It's the foundation of communities, commerce, democracy, in truth - everything.? And Schneier deals extensively with social and moral pressures that effect trust.??????
Liars and Outliers is very similar to books Umberto Eco, that have a Renaissance feel to them; bringing myriad and diverse topics together.? Schenier does this here and intertwines topics such as game theory, evolution, surveillance, existentialism and much more.? Schneier?s brilliance is that he is able to connect seemingly disparate dots around information security and society, and show how they are in truth tightly coupled.
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In the book, Schneier makes note of those that don?t follow the rules. He calls these people defectors, and these are the liars and outliers of the book.? The book notes that everything is a trade-off, and these defectors are the ones that try to break the rules.?
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An overall theme of the book, in which Schneier touches and references sociology, psychology, economics, criminology, anthropology, game theory and much more, is that society can?t function without trust.? He writes that in our complex interconnect and global society, that we need a lot of trust.?
Schneier makes frequent reference to Dunbar?s number, which he first references in chapter 2.? Dunbar's number was first proposed by British anthropologist Robin Dunbar and is a theoretical cognitive limit to the number of people with whom one can maintain stable social relationships.? It is generally in the area of 150.? So when someone sees a person with 3,000 Facebook friends, something is clearly amiss.
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In chapter 9 on institutional pressures, Schneier takes a very broad look at threats facing society today.? One of the biggest perceived threats we have today is terrorism, and the book astutely notes that we can never ensure perfect security against terrorism.?
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If Schneier had his way, the TSA budget would be measured in the millions, not billions of dollars.? He incisively observes that all the talk of terrorism as an existential threat to society is utter nonsense.? As long as terrorism is rare enough (which it is), and most people survive (which they do), society will survive.? He writes that while that observation is true, it is not politically viable for our leaders to come out and say that.?
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While the book is heavy on the people focus, Schneier also acknowledges that sometimes and for some people, the incentives to commit crimes are worth the risk.? To deal with those, that is where security technologies come into play.
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An interesting observation made in chapter 10 around technology is that sometimes the technological changes have absolutely nothing to do with the societal dilemma being secured.? For example, he notes that between the ubiquity of keyboards and the tendency for teachers to focus on standardized tests, cursive is no longer being taught that much in schools.? The result is that signatures are more likely to be either printed text is an illegible scrawl; making them easier to forge.? Which in turns creates new security risks.
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In the book Schneier makes scores of astute observations on how society functions around security.? He notes in chapter 16 that we are currently in a period of history where technology is changing faster than it ever has.? The worry is that if technology changes too fast, the attackers will be able to innovate so much faster than society can that the imbalance become even greater; with failures that negatively affect society.?
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In many of the examples in the book, Schneier paints a dark picture given the advantage that the attackers and defectors have.? But he also notes that we are in a period of history where the ability for large-scale cooperation is greater than it has ever been before. On that topic, he refers to the book The Penguin and the Leviathan: How Cooperation Triumphs over Self-Interest by Yochai Benkler where he writes that the Internet can and has enabled cooperation on a scale never before seen.? And that politics, backed by science, is ready to embrace this new cooperation.
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On the lighter side, in chapter 17, Schneier notes that Mussolini didn?t make the trains run on time; he just made it illegal to complain about them.
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Schneier notes at the end of the book that its lesson isn?t that defectors will inevitably ruin everything for everyone.? Rather that we as a society need to manage societal pressure to ensure that they don?t.?
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Liars and Outliers is an absolutely fascinating and groundbreaking book.? In this election year where the candidates attempt to make sweeping simplistic promises to fix complex problems, Schneier simply answers that in our complex society, there are no simple answers.?
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In Applied Cryptography Bruce Schneier demonstrated he was quite the smart guy.? In Liars and Outliers, he shows he is even smarter than most of us first thought.
[unable to retrieve full-text content]AP - An assistant coach of the Creighton University women's basketball team has been arrested on suspicion of drunken driving.
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Public release date: 28-Feb-2012
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